The Lomakin Lab
* equal first-authors
Ω co-corresponding authors
א authors jointly supervised the project
Lomakin AJ*Ωא, Cattin CJ*, Cuvelier D, Alraies Z, Molina M, Nader GPF, Srivastava N, Sáez PJ, Garcia-Arcos JM, Zhitnyak IY, Bhargava A, Driscoll MK, Welf ES, Fiolka R, Petrie RJ, De Silva NS, González-Granado JM, Manel N, Lennon-Duménil AM, Müller DJΩ, Piel MΩא. The nucleus acts as a ruler tailoring cell responses to spatial constraints. Science. 2020 Oct 16;370(6514).
Preview: Shen Z, Niethammer P. A cellular sense of space and pressure. Science. 2020. 370: 295-296.
Highlight: Long JT, Lammerding J. Nuclear Deformation Lets Cells Gauge their Physical Confinement. Developmental Cell. 2021. 56: 156-158.
Covered: Olena A. Nucleus Is Key to How Cells Sense Personal Space. The Scientist Magazine. Oct 15, 2020.
Evaluation: Faculty of 1000
3 key publications relevant to our core expertise:
* equal first-authors
Ω co-corresponding authors
Lomakin AJ*, Lee KC*, Han SJ, Bui DA, Davidson M, Mogilner AΩ, Danuser GΩ. Competition for actin between two distinct F-actin networks defines a bistable switch for cell polarization. Nature Cell Biology. 2015 Nov;17(11):1435-45.
Cover article of the issue: https://www.nature.com/ncb/volumes/17/issues/11
Competition for actin between two distinct F-actin networks determines whether epithelial cells remain stationary or migrate.
Lomakin AJ, Semenova I, Zaliapin I, Kraikivski P, Nadezhdina E, Slepchenko BM, Akhmanova A, Rodionov V. CLIP-170-dependent capture of membrane organelles by microtubules initiates minus-end directed transport. Developmental Cell. 2009 Sep;17(3):323-33.
Evaluation: Faculty of 1000
Most recent and previous contributions relevant to ongoing projects in the lab:
Ju RJ, Falconer AD, Dean KM, Fiolka RP, Sester DP, Nobis M, Timpson P, Lomakin AJ, Danuser G, White MD, Oelz DB, Haass NK, Stehbens SJ. Compression-dependent microtubule reinforcement comprises a mechanostat which enables cells to navigate confined environments.
Nature Cell Biology. 2024.
García-Arcos JM, Ziegler J, Grigolon S, Reymond L, Shajepal G, Cattin CJ, Lomakin A, Müller DJ, Ruprecht V, Wieser S, Voituriez R & Piel M. Advected percolation in the actomyosin cortex drives amoeboid cell motility. Developmental Cell. 2024.
Belhadj J, Surina S, Hengstschläger M, Lomakin AJ. Form follows function: Nuclear morphology as a quantifiable predictor of cellular senescence. Aging Cell. 2023 Dec;22(12):e14012.
Lomakin AJ, Kraikivski P, Semenova I, Ikeda K, Zaliapin I, Tirnauer JS, Akhmanova A, Rodionov V. Stimulation of the CLIP-170--dependent capture of membrane organelles by microtubules through fine tuning of microtubule assembly dynamics. Molecular Biology of the Cell. 2011 Nov;22(21):4029-37.
* equal first-authors
Nadezhdina ES*, Lomakin AJ*, Shpilman AA, Chudinova EM, Ivanov PA. Microtubules govern stress granule mobility and dynamics.
Biochimica et Biophysica Acta (BBA). 2010 Mar;1803(3):361-71.
Lomakin AJ, Semenova I, Zaliapin I, Kraikivski P, Nadezhdina E, Slepchenko BM, Akhmanova A, Rodionov V. CLIP-170-dependent capture of membrane organelles by microtubules initiates minus-end directed transport. Developmental Cell. 2009 Sep;17(3):323-33.
Complete list of publications:
Medical University of Vienna
Center for Pathobiochemistry and Genetics
