The Lomakin Lab
* equal first-authors
Ω co-corresponding authors
א authors jointly supervised the project
Lomakin AJ*Ωא, Cattin CJ*, Cuvelier D, Alraies Z, Molina M, Nader GPF, Srivastava N, Sáez PJ, Garcia-Arcos JM, Zhitnyak IY, Bhargava A, Driscoll MK, Welf ES, Fiolka R, Petrie RJ, De Silva NS, González-Granado JM, Manel N, Lennon-Duménil AM, Müller DJΩ, Piel MΩא. The nucleus acts as a ruler tailoring cell responses to spatial constraints. Science. 2020 Oct 16;370(6514).
Preview: Shen Z, Niethammer P. A cellular sense of space and pressure. Science. 2020. 370: 295-296.
Highlight: Long JT, Lammerding J. Nuclear Deformation Lets Cells Gauge their Physical Confinement. Developmental Cell. 2021. 56: 156-158.
Covered: Olena A. Nucleus Is Key to How Cells Sense Personal Space. The Scientist Magazine. Oct 15, 2020.
Evaluation: Faculty of 1000
3 key publications relevant to our core expertise:
* equal first-authors
Ω co-corresponding authors
Lomakin AJ*, Lee KC*, Han SJ, Bui DA, Davidson M, Mogilner AΩ, Danuser GΩ. Competition for actin between two distinct F-actin networks defines a bistable switch for cell polarization. Nature Cell Biology. 2015 Nov;17(11):1435-45.
Cover article of the issue: https://www.nature.com/ncb/volumes/17/issues/11
Competition for actin between two distinct F-actin networks determines whether epithelial cells remain stationary or migrate.
Lomakin AJ, Semenova I, Zaliapin I, Kraikivski P, Nadezhdina E, Slepchenko BM, Akhmanova A, Rodionov V. CLIP-170-dependent capture of membrane organelles by microtubules initiates minus-end directed transport. Developmental Cell. 2009 Sep;17(3):323-33.
Evaluation: Faculty of 1000
Most recent and previous contributions relevant to ongoing projects in the lab:
Herrera-Fernández V, Hengstschläger M, Lomakin AJ. Ameboid cell inchworming: An adaptive phenotype triggered by abiotic-like stress. Developmental Cell. 2025.
Ju RJ, Falconer AD, Dean KM, Fiolka RP, Sester DP, Nobis M, Timpson P, Lomakin AJ, Danuser G, White MD, Oelz DB, Haass NK, Stehbens SJ. Compression-dependent microtubule reinforcement comprises a mechanostat which enables cells to navigate confined environments.
Nature Cell Biology. 2024.
García-Arcos JM, Ziegler J, Grigolon S, Reymond L, Shajepal G, Cattin CJ, Lomakin A, Müller DJ, Ruprecht V, Wieser S, Voituriez R & Piel M. Advected percolation in the actomyosin cortex drives amoeboid cell motility. Developmental Cell. 2024.
Belhadj J, Surina S, Hengstschläger M, Lomakin AJ. Form follows function: Nuclear morphology as a quantifiable predictor of cellular senescence. Aging Cell. 2023 Dec;22(12):e14012.
Lomakin AJ, Kraikivski P, Semenova I, Ikeda K, Zaliapin I, Tirnauer JS, Akhmanova A, Rodionov V. Stimulation of the CLIP-170--dependent capture of membrane organelles by microtubules through fine tuning of microtubule assembly dynamics. Molecular Biology of the Cell. 2011 Nov;22(21):4029-37.
* equal first-authors
Nadezhdina ES*, Lomakin AJ*, Shpilman AA, Chudinova EM, Ivanov PA. Microtubules govern stress granule mobility and dynamics.
Biochimica et Biophysica Acta (BBA). 2010 Mar;1803(3):361-71.
Lomakin AJ, Semenova I, Zaliapin I, Kraikivski P, Nadezhdina E, Slepchenko BM, Akhmanova A, Rodionov V. CLIP-170-dependent capture of membrane organelles by microtubules initiates minus-end directed transport. Developmental Cell. 2009 Sep;17(3):323-33.
Complete list of publications:
Open Science:
Medical University of Vienna
Center for Pathobiochemistry and Genetics
